• Balasubramanian P, Sirivelu MP, Weiss KA, Wagner JG, Harkema JR, Morishita M,
    Mohankumar PS, Mohankumar SM. (2013) Differential effects of inhalation exposure to
    PM(2.5) on hypothalamic monoamines and corticotrophin releasing hormone in lean
    and obese rats. Neurotoxicology. 36:106-111. PubMed PMID: 22426024.

  • Blazek A, Rustky J, Osei K, Maiseyeu A, Sanjay Rajagopalan. (2013) Exercise-mediated
    changes in high-density lipoprotein: Impact on form and function. American Heart Journal.
    166(3):392-400. PubMed PMID: 24016485.

  • Brook RD, Bard RL, Kaplan MJ, Yalavarthi S, Morishita M, Dvonch JT, Wang L,
    Yang HY, Spino C, Mukherjee B, Oral EA, Sun Q, Brook JR, Harkema J, Rajagopalan S.
    (2013) The effect of acute exposure to coarse particulate matter air pollution in a rural
    location on circulating endothelial progenitor cells: results from a randomized controlled
    study. Inhal Toxicol. 25(10):587-592. PubMed PMID: 23919441.

  • Brook RD, Xu X, Bard RL, Dvonch JT, Morishita M, Kaciroti N, Sun Q, Harkema J,
    Rajagopalan S. (2013) Reduced metabolic insulin sensitivity following sub-acute
    exposures to low levels of ambient fine particulate matter air pollution. Sci
    Total Environ. 448:66-71. PubMed PMID: 22901427.

  • Brook RD, Bard RL, Morishita M, Dvonch JT, Wang L, Yang HY, Spino C, Mukherjee B,
    Kaplan MJ, Yalavarthi S, Oral EA, Ajluni N, Sun Q, Brook JR, Harkema J, Rajagopalan S. (2014)
    Hemodynamic, Autonomic, and Vascular Effects of Exposure to Coarse Particulate Matter
    Air Pollution from a Rural Location. Environ Health Perspect; 122; 624-30.
    PubMed PMID: 24618231.

  • Byrd JB, Morishita M, Bard RL, Das R, Wang L, Sun Z, Spino C, Harkema J, Dvonch JT,
    Rajagopalan S, Brook RD (2016). Acute increase in blood pressure during inhalation of coarse particulate
    matter air pollution from an urban location. J Am Soc Hypertens. 10(2):133-139.e4.
    PubMed PMID: 26750378.

  • Kumagai K, Lewandowski R, Jackson-Humbles DN, Li N, Van Dyken SJ, Wagner JG,
    Harkema JR (2015). Ozone-induced Nasal Type 2 Immunity in Mice is Dependent on Innate
    Lymphoid Cells. Am J Respir Cell Mol Biol. [Epub ahead of print] PubMed PMID: 26559808.

  • Liu C, Bai Y, Xu X, Sun L, Wang A., Wang TY, Maurya SK, Periasamy M, Morishita M, Harkema J,
    Ying Z, Sun Q, Rajagopalan S. (2014) Exaggerated effects of particulate matter air pollution in genetic
    type II diabetes mellitus. Particle Fibre Toxicol. 11:27. PubMed PMID: 24886175.

  • Liu C, Xu X, Bai Y, Wang TY, Rao X, Wang A, Sun L, Ying Z, Gushchina L,
    Maiseyeu A, Morishita M, Sun Q, Harkema JR, Rajagopalan S. 2014. Air Pollution-Mediated
    Susceptibility to Inflammation and Insulin Resistance: Influence of CCR2 Pathways in Mice.
    Environ Health Perspect. 122:17-26. PubMed PMID: 24149114.

  • Liu C, Zheing Y, Harkema J, Sun Q, Rajagopalan S. (2013) Epidemiological and
    Experimental Links between Air Pollution and Type 2 Diabetes. Toxicol Pathol.
    41(2):361-373. PubMed PMID: 23104765.

  • Maiseyeu A, Yang HY, Ramanathan G, Yin F, Bard RL, Morishita M, Dvonch JT,
    Wang L, Spino C, Mukherjee B, Badgeley MA, Barajas-Espinosa A, Sun Q, Harkema J,
    Rajagopalan S, Araujo JA, Brook RD. (2014) No effect of acute exposure to coarse
    particulate matter air pollution in a rural location on high-density lipoprotein
    function. Inhal Toxicol. 26(1):23-9. PubMed PMID: 24417404.

  • Morishita M, Bard RL, Kaciroti N, Fitzner CA, Dvonch T, Harkema JR,
    Rajagopalan S, Brook RD. (2014) Exploration of the composition and sources of urban fine
    particulate matter associated with same-day cardiovascular health effects in Dearborn, Michigan.
    J Expo Sci Environ Epidemiol [Epub ahead of print] PubMed PMID: 24866265.

  • Morishita M, Bard RL, Wang L, Das R, Dvonch JT, Spino C, Mukherjee B, Sun Q, Harkema JR,
    Rajagopalan S, Brook RD. (2014) The characteristics of coarse particulate matter air pollution associated
    with alterations in blood pressure and heart rate during controlled exposures. J Expo Sci Environ Epidemiol
    PubMed PMID: 25227729.

  • Ong CB, Kumagai K, Brooks PT, Brandenberger C, Lewandowski RP, Jackson-Humbles
    DN, Nault R, Zacharewski TR, Wagner JG, Harkema JR.(2015). Ozone-Induced Type 2 Immunity
    in Nasal Airways: Development and Lymphoid Cell Dependence in Mice. Am J Respir
    Cell Mol Biol. [Epub ahead of print] PubMed PMID: 26203683.

  • Pancras JP, Landis MS, Norris GA, Vedantham R, Dvonch JT. (2013) Source
    apportionment of ambient fine particulate matter in Dearborn, Michigan, using hourly
    resolved PM chemical composition data. Sci Total Environ. 448:2-13. PubMed PMID:23302684.

  • Rao X, Zhong J, Maiseyeu A, Gopalakrishnan B, Villamena FA, Chen LC, Harkema JR, Sun Q,
    Rajagopalan S. (2014) CD36-Dependent 7-Ketocholesterol Accumulation in Macrophages Mediates
    Progression of Atherosclerosis in Response to Chronic Air Pollution Exposure. Circ Res.
    PubMed PMID: 25186795.

  • Sun L, Liu C, Xu X, Ying Z, Maiseyeu A, Wang A, Allen K, Lewandowski RP, Bramble
    LA, Morishita M, Wagner JG, Dvonch JT, Sun Z, Yan X, Brook RD, Rajagopalan S,
    Harkema JR, Sun Q, Fan Z. (2013) Ambient fine particulate matter and ozone exposures
    induce inflammation in epicardial and perirenal adipose tissues in rats fed a high
    fructose diet. Part Fibre Toxicol. 10(1):43. PubMed PMID: 23968387. PMCID:PMC3765456.

  • Wagner JG, Kamal AS, Morishita M, Dvonch JT, Harkema J, Rohr AC. (2014) PM2.5-induced
    cardiovascular dysregulation in rats is associated with elemental carbon and temperature-resolved carbon subfractions.
    Particle Fibre Toxicol. 11:25. PubMed PMID: 24885999.

  • Wagner JG, Allen K, Yang HY, Nan B, Morishita M, Mukherjee B, Dvonch JT, Spino
    C, Fink GD, Rajagopalan S, Sun Q, Brook RD, Harkema JR.  (2014) Cardiovascular Depression
    in Rats Exposed to Inhaled Particulate Matter and Ozone: Effects of Diet-Induced Metabolic Syndrome.
    Environ Health Perspect. 122: 27-33. PubMed PMID: 24169565.

  • Ying Z, Xu X, Bai Y, Zhong J, Chen M, Liang Y, Zhao J, Liu D, Morishita M, Sun Q, Spino C,
    Brook RD, Harkema JR, Rajagopalan S. (2014) Long-Term Exposure to Concentrated Ambient PM2.5
    Increases Mouse Blood Pressure through Abnormal Activation of the Sympathetic Nervous System: A
    Role for Hypothalamic Inflammation. Environ Health Perspect. 122: 79-86. PubMed PMID: 24240275.

  • Ying Z, Xu X, Chen M, Liu D, Zhong M, Chen LC, Sun Q, Rajagopalan S. (2013) A Synergistic Vascular
    Effect of Airborne Pariculate Matter and Nickel in a Mouse Model. Toxicol Sci. PubMed PMID: 23788629.

  • Ying Z, Allen K, Zhong J, Chen M, Williams KM, Wagner JG, Lewandowski R, Sun Q, Rajagopalan S, Harkema JR. (2016)
    Subacute inhalation exposure to ozone induces systemic inflammation but not insulin resistance in a diabetic mouse model.
    Inhal Toxicol. 4:155-63. PubMed PMID: 26986950.

  • Zhong J, Allen K, Rao X, Ying Z, Braunstein Z, Kankanala SR, Xia C, Wang X, Bramble LA, Wagner JG, Lewandowski R,
    Sun Q, Harkema JR, Rajagopalan S. (2016) Repeated Ozone Exposure Exacerbates Insulin Resistance And Activates
    Innate Immune Response In Genetically Susceptible Mice. Inhal Toxicol. 1-10. [Epub ahead of print] PubMed PMID: 27240593.


  • Brook RD, Rajagopalan S, Pope CA 3rd, Brook JR, Bhatnagar A, Diez-Roux AV, Holguin F, Hong Y,
    Luepker RV, Mittleman MA, Peters A, Siscovick D, Smith SC Jr, Whitsel L, Kaufman JD. (2010)
    Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the
    American Heart Association. American Heart Association Council on Epidemiology and Prevention, Council
    on the Kidney in Cardiovascular Disease, and Council on Nutrition, Physical Activity and Metabolism. Circulation.
    121(21):2331-78. PubMed PMID: 20458016.

  • Zhao X, Sun Z, Ruan Y, Yan J, Mukherjee B, Yang F, Duan F, Sun L, Liang R, Lian H, Zhang S, Fang Q,
    Gu D, Brook JR, Sun Q, Brook RD, Rajagopalan S, Fan Z. (2014) Personal Black Carbon Exposure Influences
    Ambulatory Blood Pressure: Air Pollution and Cardiometabolic Disease (AIRCMD-China) Study. Hypertension.  
    PubMed PMID: 24420543.

  • Brook RD, Cakmak S, Turner MC, Brook JR, Crouse DL, Peters PA, van Donkelaar A, Villeneuve PJ,
    Brion O, Jerrett M, Martin RV, Rajagopalan S, Goldberg MS, Pope CA 3rd, Burnett RT. (2013) Long-term
    fine particulate matter exposure and mortality from diabetes in Canada. Diabetes Care. 36(10):3313-20.
    PubMed PMID: 23780947.

  • Sun Z, Mukherjee B, Brook RD, Gatts GA, Yang F, Sun Q, Brook JR, Fan Z, Rajagopalan S. (2013)
    Air-Pollution and Cardiometabolic Diseases (AIRCMD): a prospective study investigating the impact of air
    pollution exposure and propensity for type II diabetes. Sci Total Environ. 448:72-8. PubMed PMID: 23182147.

    GLOBAL HEALTH. Glob Heart. 7(3):207-213. PubMed PMID: 23181202.

  • Rajagopalan S, Brook RD. (2012) Air pollution and type 2 diabetes: mechanistic insights. Diabetes.
    61(12):3037-45. Review. PubMed PMID: 23172950.

  • Brook RD, Rajagopalan S. (2012) Chronic air pollution exposure and endothelial dysfunction: what you
    can't see--can harm you. J Am Coll Cardiol. 60(21):2167-9. PubMed PMID: 23103034.

  • Brook RD, Rajagopalan S. (2012) Can what you breathe trigger a stroke within hours?: Comment on
    "Ambient air pollution and the risk of acute ischemic stroke". Arch Intern Med. 172(3):235-6.
    PubMed PMID: 22332154.

  • Kampfrath T, Maiseyeu A, Ying Z, Shah Z, Deiuliis JA, Xu X, Kherada N, Brook RD, Reddy KM, Padture NP,
    Parthasarathy S, Chen LC, Moffatt-Bruce S, Sun Q, Morawietz H, Rajagopalan S. (2011) Chronic fine particulate
    matter exposure induces systemic vascular dysfunction via NADPH oxidase and TLR4 pathways. Circ Res.
    108(6):716-26. PubMed PMID: 21273555.

  • Brook RD, Rajagopalan S. (2010) Particulate matter air pollution and atherosclerosis. Curr Atheroscler Rep.
    12(5):291-300. Review. PubMed PMID: 20617466.

  • Xu Z, Xu X, Zhong M, Hotchkiss IP, Lewandowski RP, Wagner JG, Bramble LA, Yang Y, Wang A,
    Harkema JR, Lippmann M, Rajagopalan S, Chen LC, Sun Q. (2011) Ambient particulate air pollution
    induces oxidative stress and alterations of mitochondria and gene expression in brown and white adipose tissues.
    Part Fibre Toxicol. 8:20. PubMed PMID: 21745393.

  • Kamal AS, Rohr AC, Mukherjee B, Morishita M, Keeler GJ, Harkema JR, Wagner JG. (2011)
    PM2.5-induced changes in cardiac function of hypertensive rats depend on wind direction and specific sources
    in Steubenville, Ohio. Inhal Toxicol. 23(7):417-30. PubMed PMID: 21639710.

  • Rohr AC, Kamal A, Morishita M, Mukherjee B, Keeler GJ, Harkema JR, Wagner JG. (2011) Altered heart
    rate variability in spontaneously hypertensive rats is associated with specific particulate matter components in
    Detroit, Michigan. Environ Health Perspect. 119(4):474-80. PubMed PMID: 21163724.

  • Carey SA, Ballinger CA, Plopper CG, McDonald RJ, Bartolucci AA, Postlethwait  EM, Harkema JR.
    (2011) Persistent rhinitis and epithelial remodeling induced by cyclic ozone exposure in the nasal airways
    of infant monkeys. Am J Physiol Lung Cell Mol Physiol. 300(2):L242-54. PubMed PMID: 21131400.

  • Li N, Harkema JR, Lewandowski RP, Wang M, Bramble LA, Gookin GR, Ning Z, Kleinman MT, Sioutas C,
    Nel AE. (2010) Ambient ultrafine particles provide a strong adjuvant effect in the secondary immune response:
    Implication for traffic-related asthma flares. Am J Physiol Lung Cell Mol Physiol.
    299(3):L374-83. PubMed PMID: 20562226.

  • Rohr AC, Wagner JG, Morishita M, Kamal A, Keeler GJ, Harkema JR. (2010) Cardiopulmonary responses
    in spontaneously hypertensive and Wistar-Kyoto rats exposed to concentrated ambient particles from
    Detroit, Michigan. Inhal Toxicol. 22(6):522-33. PubMed PMID: 20384466.

  • Aibo DI, Birmingham NP, Lewandowski R, Maddox JF, Roth RA, Ganey PE, Wagner JG, Harkema JR. (2010)
    Acute exposure to ozone exacerbates acetaminophen-induced liver injury in mice. Toxicol Sci.
    115(1):267-85. PubMed PMID: 20123758.

  • Kang X, Li N, Wang M, Boontheung P, Sioutas C, Harkema JR, Bramble LA, Nel AE, Loo JA. (2010) Adjuvant
    effects of ambient particulate matter monitored by proteomics of bronchoalveolar lavage fluid. Proteomics.
    10(3):520-31. PubMed PMID: 20029843.

  • Li N, Wang M, Bramble LA, Schmitz DA, Schauer JJ, Sioutas C, Harkema JR, Nel AE. (2009) The adjuvant effect of
    ambient particulate matter is closely reflected by the particulate oxidant potential. Environ Health Perspect.
    117(7):1116-23.  PubMed PMID: 19654922.

  • Brook RD, Urch B, Dvonch JT, Bard RL, Speck M, Keeler G, Morishita M, Marsik FJ, Kamal AS, Kaciroti N, Harkema J,
    Corey P, Silverman F, Gold DR, Wellenius G, Mittleman MA, Rajagopalan S, Brook JR. (2009) Insights into the
    mechanisms and mediators of the effects of air pollution exposure on blood pressure and vascular function in healthy humans.
    Hypertension. 54(3):659-67. PubMed PMID: 19620518.

  • Wagner JG, Harkema JR, Jiang Q, Illek B, Ames BN, Peden DB. (2009) Gamma-tocopherol  attenuates
    ozone-induced exacerbation of allergic rhinosinusitis in rats. Toxicol Pathol. 37(4):481-91. PubMed PMID: 19389874.

  • Heidenfelder BL, Reif DM, Harkema JR, Cohen Hubal EA, Hudgens EE, Bramble LA, Wagner JG,
    Morishita M, Keeler GJ, Edwards SW, Gallagher JE. (2009) Comparative microarray analysis and pulmonary
    changes in Brown Norway rats exposed to ovalbumin and concentrated air particulates. Toxicol Sci.
    108(1):207-21. PubMed PMID: 19176365.